Independiente held on for a 0-0 draw with 10 men against fellow Argentine club Boca Juniors to reach the Copa Sudamericana last 16.
Independiente, the 2010 Copa Sudamericana champions, drew the first-leg 3-3 away at Boca and despite being down to 10 men in the second half of Wednesday s match following Eduardo Tuzzio s dismissal, they managed to see out the scoreless stalemate and advance on the away goals rule.
Americo Gallego s side will now face the winner of Uruguay s Liverpool and Colombia s Envigado in the round of 16.
In other results, Cerro Porteno lost a two-goal lead after Sebastian Taborda was sent off, as they drew 2-2 in their first-leg clash away to Atletico Club Mineros.
Nacional grabbed a crucial 1-0 away win in their first leg against LDU Loja, while Universidad Catolica got off to a good start in front of their home fans with a 2-0 win over Deportes Tolima.